|“||Blood only runs so deep when you're related to vampires.||”|
Zachary "Zach" Salvatore was Stefan and Damon Salvatore's distant nephew and also the father of Sarah Salvatore. He was a descendant of Stefan and Damon's half-brother. He was a member of the Town Council (their supplier of vervain) and was killed by Damon Salvatore.
Zach Salvatore was a distant nephew of Stefan and Damon Salvatore. He lived alone at the Salvatore Boarding House until his vampire uncle, Stefan Salvatore, came to live with him after a short visit.  He was unhappy about this, especially after a number of "animal attacks" occurred in town. He also didn't like the presence of Stefan's brother Damon Salvatore who came to Mystic Falls due to the fact that he followed his brother to torment him.
Zach showed Stefan that he had been growing vervain in the basement and they could use it to stop Damon from hurting anyone else. They failed at the first attempt but Stefan managed to spike Caroline Forbes's drink with vervain, thus weakening Damon when he bit her. Zach later visited the basement where they had Damon locked up. Zach told him that he had vervain in his system for several years and it wouldn't help to kill and drink his blood. Damon tried to strangle Zach until Stefan saved him.
Throughout Zach's time in Mystic Falls during Season 1, he and Damon had a violent relationship (on Damon's part). Zach encouraged Stefan to find any way to kill Damon.
Damon showed he still had an influence over Caroline and compelled her to free him. He attempted to kill her for blood but Zach tried to stop him. Damon broke Zach's neck and pursued Caroline but failed as he couldn't go out in the sun. Later, Stefan found his body and realized what Damon had done.
In the present day, it seems unsure whether anyone knows of Zach's death besides Stefan, Damon, and Elena Gilbert. Damon told The Town Council that Zach had gone away and he continued to supply the Council with Zach's vervain, taking over Zach's responsibilities with the council.
In Black Hole Sun, Zach appears in flashbacks to 1994, along with his pregnant girlfriend Gail. He invites Damon into the Salvatore Boarding House for the first time, resulting in Damon meeting his girlfriend Gail, who he later feeds on and murders. The baby Sarah survived and was adopted right out of the hospital after Stefan compels him to forget the child and her mother.
- Memorial (Only mentioned)
- Black Hole Sun (flashback)
Zach is a nickname for Zachariah. Zach is a Hebrew name and it means "The Lord remembers".
- Zach Salvatore didn't like vampires and the reason why he didn't have a family was because of the risk of them dying or getting turned into a vampire by Damon.
- He nearly did start a family of his own, but Damon ruined it by killing his girlfriend Gail and he never had a chance to raise Sarah since he thought she was dead.
- Zach refers to Stefan as "Uncle Stefan", while Stefan (in his secret identity as a high school student) tells people that he lives with his Uncle Zach.
- Zach was the vervain supplier for The Town Council.
- Zach favored Stefan over Damon.
- Zach was named after his ancestor Zachariah Salvatore.