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Werewolf Bite

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A Werewolf Bite is an extremely poisonous and toxic fluid that is produced by the saliva glands within a werewolf and hybrid's mouth. The venom is commonly transmitted into vampires as a means of infecting and

Klaus biting Will

eventually killing vampires. Whenever a vampire is bitten by a werewolf or hybrid, the poison will be passed from the wolf's mouth into the vampire's bloodstream. Once the blood is contaminated by the toxic fluids, the vampire's heart will pump the venom throughout their cardiovascular system which will cause the venom to infect every cell it passes within the body. During which time, the vampire will become increasingly pale. The length of time needed for the saliva to destroy the bitten vampire is debatable upon vampires. After bitten by a very experienced wolf named Jules, the vampire Rose rapidly deteriorated until Damon euthanized her the night after. On the other hand, when Damon himself was bitten by  Tyler Lockwood, a werewolf on his second full moon, it took approximately three days for him to be on the verge of death until cured by Klaus. A wolf’s bite will also cause a vampire to hallucinate and go rabid as if it was a wild animal, causing them to lash out violently on occasion, and the death is extremely slow and painful. Werewolf bites cannot kill an Original Vampire, as Elijah mentioned to Elena when they were talking about how to kill Klaus. However, it does weaken them temporarily as Rebekah felt dizzy and hallucinated after drinking a concentrated dose of hybrid venom. It wore off quickly, she just had to rest for an hour or so to heal completely.

In The Rager it is shown that somebody can take werewolf\hybrid venom via injection needle and place it in something (ex. a drink) and it will affect any vampire who drinks it. Unlike werewolves, the bite of a hybrid takes just a few hours to kill.

The Cure

The two only know cures to the bite of a werewolf bite are the blood of the original hybrid Klaus or that of his daughter Hope. However, Dr. Wes Maxfield thought it possible to synthesize a cure from the venom of a werewolf itself, this theory was never tested.


It has not been shown how a werewolf bite would affect a human should they survive a werewolf attack (unlikely due to their ferocity and above-vampire prowess). So, the poison from the werewolf bite may or may not have any effect on a human. When vampire hunter Connor infected the beer from Rebekah's party with Hybrid saliva, many humans drank from it seemingly without consequences.

Vampires bitten by Werewolves/Hybrids











Marcel's Army





  • Damon, Elena and Rebekah are the only main vampires who were infected without a bite of a werewolf. (Though Damon has been infected with a werewolf bite before)
  • Damon killed Rose and Will before the effects of the werewolf bite. 
  • Nadia Petrova is the first and only vampire shown on screen to die of a werewolf/hybrid bite so far.
  • It was speculated by Wes Maxfield that because werewolf venom is a toxin, it could presumably have an antidote created by scientific means rather than Klaus' blood. However this was never proven only mere speculation. Though the enhanced Ripper Compound infecting Elena that he made, which bore elements of Werewolf Venom were later cured thanks to the antidote delivered by Enzo.
  • Mikael is probably immune to werewolf bite. In From a Cradle to a Grave he drank blood of vampires bitten by werewolves and werewolf's venom didn't injure him, however, it is very likely that the venom, just didn't take effect immediately. However, it was later revealed that Mikael is simply capable of fighting through the effects due to great focus, and while weakened, is not as weakened as Elijah or Rebekah were when they had been bitten.

See also

Start a Discussion Discussions about Werewolf Bite

  • Hybrids

    2 messages
    • How does the full moon affect a Hybrid's powers and abilities?
    • I believe Hybrids still feel the effects of a full moon. E.g. Increased anger and aggression, which by extension would increase their physi...
  • How this Bayou Pack situation is a "curse" still confuses me?

    4 messages
    • i think they said they only human on the full moon but yea i agree if they can mess up rebekah like that they can obviously take down some vampires
    • They are forced to live as wolves other than the nights of fullmoon.  I suppose no being with any degree of  humanity must to live that long...

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