|“|| Klaus: Go ahead, Rebekah. Tell him. Tell him what the hunter told you the tattoo leads to. What is this great weapon that could bring about the end of the vampire species?
Rebekah: A cure. He said there was a cure.
The Cure, also known as the Cure for Immortality or the Cure for Vampirism, is one the three known ways to reverse vampirism. The second cure was created by Esther in the form of a spell for her children. The final cure is a spell invented by the Travelers using the blood from the last pair of doppelgängers and a minor version of the Magic Purification Spell.
It is a potion created by the witch Qetsiyah to reverse immortality. When used on immortal beings, they are reverted to their mortal states and are thus vulnerable to death. The cure when ingested by a doppelgänger converts the blood of the given doppelgänger, causing it to become a liable candidate for a single dose if ingested and if the doppelgänger in question had lived beyond human years, the post-cure effects would begin to cause him/her to age and eventually die as happened with Katherine Pierce.
Recently, it was discovered that two alternate dimensions created by a very powerful coven in 1903 and 1994, the effects of these alternate realms duplicated all magical items, objects, and talisman, the ripple effect creating alternate versions of the cure as it is an object and a powerful magical item. The 1994 version of the cure was discovered by Bonnie Bennett while searching for Silas' Tombstone in the alternate Nova Scotia and she took it back to the original earth dimension. Its alternate existence was first insinuated by Damon. The 1994 cure is running through Elena's veins.
The cure was once a part of the Petrova Family when its status belonged to Katherine Pierce, Amara and a member of the Salvatore Family when ingested by Silas. The cure was once again a part of the Petrova Family since Elena Gilbert ingested the 1994 version of it until Bonnie injected some of the cure on Stefan Salvatore and is also a part of the Salvatore Family.
Ancient Greece (1st Century B.C.)
After Silas stole the Immortality Elixir and left Qetsiyah at the altar, she found him in the wilderness with the woman he gave her immortality to: her handmaiden, Amara. Qetsiyah, furious at Silas for his betrayal, faked Amara's death and decided to give Silas a second chance with her by creating a cure for immortality, which she offered to him; she promised that she would take him back if he took the cure and spent out the remainder of their mortal lives with her. Silas, however, refused to take it, which led to Qetsiyah seeking her revenge on him by desiccating him and entombing him with the cure on an island off the coast of Nova Scotia. She hoped that, faced with an eternity of imprisonment, he would choose to instead take the cure in order to end his suffering by dying a mortal death; if he chose this path, his soul would be trapped in the supernatural purgatory known as the Other Side, which Qetsiyah had also created in order to ensure that Silas would be trapped with her forever even in death. To her fury, Silas refused to give into her demands by taking the cure until such time has he was freed from his tomb. This way, he could merge the Other Side with the living world by lowering the Veil and eventually die a mortal death so he would be reunited with Amara in the Afterlife, rather than be trapped with Qetsiyah. For 2,000 years, the cure was buried along with Silas, until Qetsiyah's distant descendant Bonnie Bennett opened his tomb, freeing Silas and the cure.
Throughout The Vampire Diaries
In Memorial, a hunter named Connor Jordan arrived in Mystic Falls, claiming that he had come to investigate the fire that killed Pastor Young and his newly-reformed Town Council. He realized that Tyler Lockwood was a vampire after shaking his hand with his vervain-soaked gloves and seeing his hand burn, which led Connor to shoot Tyler multiple times in the chest with wooden bullets. Fortunately for Tyler, his hybrid heritage ensured that he didn't die from the attack, allowing him to get away and warn his fellow vampire friends. Connor continued attacking people, including April Young (who he stabbed to use as bait in order to reveal more vampires), as well as Tyler for a second time. Later, Jeremy and Matt saw him sitting at the bar at the Grill. Jeremy complimented Connor on his tattoo, which he saw covered at least half of his arm, but Matt scoffed at Jeremy's comment, as he couldn't see Connor's tattoo. Later, when Klaus and Damon held Connor captive, Klaus discovered, based on the symbol Connor carved into his stakes and an off-hand comment made by Damon about the fact that only Jeremy could see his tattoo, that Connor was indeed a member of the Brotherhood of the Five.
In The Five, while Connor was held captive by Klaus, Stefan later showed up, asking Klaus about the Five, since Damon had mentioned it to him. Klaus ultimately decided to be honest to Stefan about what he knew, as he knew Stefan would be interested in what having a member of the Five could mean for them, but only if Stefan helped him get Rebekah to forgive him, as he needed Rebekah's help and information for their plan. Stefan managed to get Rebekah to agree to dinner at the Mikaelson Mansion, where the two Mikaelsons explained to Stefan about their experiences with the Five. According to Klaus, the Brotherhood of the Five was a group of five supernatural hunters who were given supernatural strength and agility, as well as an immunity to any kind of mind control in order to help them in their quest to rid the world of vampires, with the ultimate goal of finding, curing, and killing Silas. The Five then turned up in Italy in the 1100's shortly after their creation when the five Mikaelson siblings were living there, and one of the hunters, Alexander, fell into a serious romantic relationship with Rebekah. During their relationship, Alexander confided to Rebekah several facts about their order, including the fact that they had a weapon that no vampire could fight against—a cure for vampirism. This cure would return any vampire to their formerly mortal state as a human, and the only way to find the location of the cure was with a map that was embedded in the Hunter's Mark tattoo on the members of the Five. Since Jeremy, as a potential hunter of the Five, was the only person would could see the tattoos, Klaus threatened to kill Jeremy if he didn't sketch Connor's tattoo for them.
They spent the next several months continuing their search for the cure, which included giving Jeremy more vampires to kill in order to activate his membership as a supernatural hunter of the Five and to completely reveal his Hunter's Mark, as well as finding the tomb where the cure was buried with Silas, with help from Professor Atticus Shane, the man who had taught Bonnie the Expression magic necessary to find it. In Down the Rabbit Hole, Bonnie and Jeremy found the cure buried with Silas, but it was fossilized in Silas' hands, and could only be removed by feeding Silas blood to wake him up. Katherine, impersonating Elena, bit Jeremy's wrist and forced his blood down Silas' throat, resulting in Silas further feeding from his neck before finally snapping his spine and killing him. While everyone was distracted with Silas' awakening, Katherine stole the cure and made off with it.
From there, the cure was sought out by many, including Stefan and Damon (who wanted it for Elena), Rebekah (who wanted it for herself), Klaus (who wanted it to ensure that it would not be used against him), and Silas. Over the span of several weeks, the cure moved from Katherine's possession to an associate of Katherine's, Lanie, who had been compelled to keep the cure safe at her home in case someone tried to come after her for it. After Rebekah had found and taken a cure decoy in Katherine's new home in Pennsylvania (which turned out to be simply an extra-concentrated dose of vervain), Katherine reluctantly gave the cure to Elijah, in hopes that Elijah could use it to help barter for Katherine's freedom from Klaus. Unfortunately, Elijah gave the cure to Silas, who had used his illusion powers to appear as Rebekah. Silas intended on bringing down the Veil between the living world and the Other Side with Bonnie's (unwilling) help, so he could finally kill himself and rejoin his true love Amara in the afterlife with no risk of ending up trapped in the supernatural purgatory with Qetsiyah. However, when Bonnie managed to neutralize Silas by desiccating him, Alaric's ghost managed to steal the cure from his body in order to give it to Damon to give to Elena, as she had wanted to be cured of vampirism since she had been turned. However, Elena ultimately decided to stay a vampire, and she instead held onto the cure, not knowing what to do with it. At the end of Graduation, Katherine, upset that Elena seemed to get all of the good things in life that she had always wanted, confronted Elena at the school and attacked her, gaining the upper-hand in the fight and shoving her fist into Elena's chest to rip out her heart. However, Elena, at a loss for options, grabbed the cure from her purse and shoved it down Katherine's throat, forcing her to fully ingest it and knocking her unconscious. When she awoke, she had been transformed back into a human/Traveler.
In I Know What You Did Last Summer, it was revealed that Katherine had spent the last several months on the run, as she was fearful that once all of the people she had screwed over in her long life figured out she was a human again, they would take advantage of her vulnerability and kill her for her various past betrayals. She sought protection from Damon at the Salvatore Boarding House, which he reluctantly allowed. However, Silas, who had spent the summer parading as Stefan while the real Stefan was locked in a large safe thrown at the bottom of a quarry, was also revealed to be seeking Katherine, and immediately tracked down Damon in order to use his psychic powers to read his mind and find out where Katherine was hiding. He then showed up at the boarding house, still pretending to be Stefan, and tried to seduce her in order to get close enough to her to capture her; unfortunately for him, Katherine's suspicious and paranoid nature picked up on his intentions, and she barely managed to get away from him before he could attack her.
In Original Sin, it was revealed that Silas (who had teamed up with Nadia when he learned her mysterious agenda aligned with his own) was seeking Katherine out because once Katherine ingested the cure, her blood became the cure, and feeding on all of her blood would allow Silas to cure himself and return to being a Traveler witch. He pursued her for several days until Monster's Ball, when he finally succeeded on feeding on Katherine's blood with Damon's assistance, though Katherine did not end up dying as she was expected to do. Also, as a result of ingesting Katherine's cure-laced blood, Silas' own blood became the new cure.
In Handle with Care, it was revealed that Katherine taking the cure had a negative affect on her now-human body, which had begun to age aggressively to compensate for the 700+ years that Katherine had been alive. These consequences included Katherine's hair going gray and her teeth falling out, among other complaints. At the end of the episode, the newly-awakened Amara, upon hearing that Silas had ingested the cure, stabbed Silas in the neck and fed on his blood so she, too, could cure herself of the immortality she had come to hate after 2,000 years of being the Anchor. It can be presumed that this led to Amara's blood becoming the cure, but this was not confirmed, as no one else attempted to cure themselves with her blood, likely in part due to the negative consequences Katherine had experienced due to her advanced age.
In A Bird in a Gilded Cage, it was revealed by Bonnie that she had brought the cure back with her after escaping from the 1994 prison world. While on the island to use the remaining magic in Silas' headstone in order to return home, she had remembered that the cure was with Silas in 1994 as no one knew about it at the time. She had taken it with the intention of giving it to Damon for Elena. Bonnie tells him do whatever he wants with it.
In I'd Leave My Happy Home For You, Elena takes the cure and becomes human again. She regains her memories of her previous relationship with Damon back as one of the cures affects is stripping away the compulsion she had Alaric do at her request in Yellow Ledbetter.
In I'll Wed You in the Golden Summertime, Damon claims that he is going to take the cure and become human again to be with Elena, and have a human life with her. Stefan tries to convince him, not to take the cure, giving him visions of what their life could be like, however, his plan fails and infarct makes the opposite effect. Damon confirms that he will take the cure. However at Alaric and Jo's wedding, Kai attacks, resulting in Elena falling into a coma.
In I'm Thinking Of You All The While, Damon will wait to take the cure until Elena wakes from her long slumber.
In You Made a Choice to Be Good, Bonnie removed a portion of the cure from Elena's body and injected into Stefan to save herself.
In I Was Feeling Epic, Stefan used a syringe to collect some of his blood, which contained the cure and then injected into Damon when he was trying to send Katherine back to hell.
- Qetsiyah (Creator; Formerly)
- Lanie (Formerly)
- Elijah Mikaelson (Formerly)
- Silas (Ingested via Katherine)
- Alaric Saltzman (Briefly/Formerly)
- Damon Salvatore (Formerly)
- Galen Vaughn (Briefly/Formerly)
- Elena Gilbert (Original version; (briefly/formerly) - 1994 version; ingested, then injected in Stefan via her blood)
- Katerina Petrova (Ingested, then drunk by Silas via her blood)
- Amara (Ingested via Silas' blood)
- Bonnie Bennett (Formerly)
- Stefan Salvatore (Injected via Bonnie, then injected in Damon via his blood)
- Damon Salvatore (injected with Stefan's blood by Stefan)
- If an immortal/vampire takes the cure, they would be free of immortality and no longer be dependent on blood for survival. They will no longer be a vampire.
- If a vampire affected with a Sire Bond takes the cure, he/she will be free of it as they will no longer be a vampire.
- If a hybrid is cured of their vampirism they will become a werewolf again and will begin turning under full moons again.
- If a vampire who was a witch takes the cure, he/she will become a witch again, as demonstrated by Silas after he ingested the cure.
- Once a vampire takes the cure, the cure will remain in their system and their blood will become the cure.
- There are three possible outcomes for the sire line of an Original Vampire who takes the cure:
- SIRE LINE REMAINS ALIVE: The Original Vampire will turn human, but due to a break in the blood connection, his sire line remains intact. Vampiric descendants of an original vampire would continue to be vampires. This would also mean there the connection between an Original and his sire line is ultimately a passive one.
- SIRELINE IS CURED: Curing an Original Vampire cures every vampire in their sire line. This would turn every vampire sired by an Original into humans and remove the link between them, which would mean the Original's death would not affect those formerly in their sire line.
- SIRELINE DIES: Curing an Original Vampire kills every vampire in the sire line. Vampires are known to share in the magic of an Original Vampire, which is why killing the Original Vampire destroys the sire line. Being cured of immortality means the magic keeping the sire line alive is destroyed thus might end up killing all vampires in the sire line
- Taking the cure: Once you take the cure you cannot be turned back into a immortal/vampire, nor can they be healed by a vampire's blood. Ingesting vampire blood will not work, and will cause a violent reaction that will force the drinker to vomit up the vampire blood they have consumed.
- As long as the cure remains in the former immortal's blood, they will continue to age normally. If the cure is drained from their blood, and the immortal has lived longer than physically possible, the former immortal's body will have to compensate for their extra years of undead life and will begin to rapidly age to the point of where they die of old age. This doesn't appear to occur as long as the cure remains in their bloodstream, however, as Katherine did not begin rapidly aging until Silas had consumed the majority of her cure-laced blood.
- To some extent, the cure also has the power of resurrection, as it can turn a vampire (an undead being) back to a human or witch (living beings).
- If a vampire who was bitten by a werewolf take the cure, he will be cured of his immortality so he will not die and will not have the werewolf bite effect anymore.
- In I'd Leave My Happy Home For You, after Elena took the cure, she regained her memories that Alaric had compelled her to forget. This means the cure would end the compulsion for any vampire who had been compelled.
- As of You Made a Choice to Be Good, almost all doppelgängers used the cure.
Teams In Order To Find The Cure
Shane wanted the cure to resurrect Silas, who he believed would bring back his dead wife and son, as they are both witches and likely on The Other Side. He needed Bonnie's help because only Qetsiyah's descendants (Bennett witches) can perform the hunter's spell, so he taught Bonnie how to practice Expression to regain her magical powers and cast the spell. After Jeremy completed his mark, he took Bonnie, Jeremy, Stefan, Rebekah, Damon and Elena to the Island to find the cure. Shane ultimately died on the island after Silas possessed his body. Later, it is revealed that the only reason Shane had been teaching Bonnie Expression was so she could do Silas' work for him after he was awakened, due to the fact that Silas' vampirism/immortality had resulted in him no longer being a witch.
Klaus claimed that he wanted the cure to give it to Elena so he can use her doppelgänger blood to create more hybrids. He forced Jeremy to kill vampires in order to complete his Hunter's Mark. Damon taught Jeremy how to fight, with help from Matt and Klaus. When Kol learns of their plan to wake Silas to obtain the cure, he begins to interfere in order to prevent them from doing it. Kol threatens to rip off Jeremy's arms so they can't find the cure, and Klaus tells him to stay away from Jeremy. Kol keeps his word, but instead compels Damon to kill Jeremy. Thankfully for both Damon and Jeremy, Stefan snaps Damon's neck and locks him in the cellar until they can break the compulsion by daggering Kol. Kol attempts to kill Elena and Jeremy, giving them no choice but to kill Kol, although Elena had been wanting to kill Kol since he compelled Damon to kill her brother. After Jeremy kills Kol, his hunter's mark completes itself, and Damon's compulsion is broken. Klaus gets extremely angry when he learns what Elena and Jeremy did to his brother, but Bonnie uses a spell to trap him in the living room of the Gilbert House until they can find the cure and use it on him to kill him. After Klaus finds out that there's only one dose of the cure, he withholds that information from anyone until he could tell Rebekah during a phone call with Caroline, knowing that if Rebekah got it first, it wouldn't be able to be used against him. He also tells her he wants her to live and die as she wishes, although it is unknown if he actually means it.
Rebekah wanted the cure to use it and be human again. With Kol and April's help, she gets information from Stefan, Caroline, Elena and Shane on their progress in finding the cure while she was daggered. Later, Rebekah and Stefan team up to find the cure first and use it for themselves. They find Silas' headstone in Shane's office and steal it as leverage; Team Rebekah and Team Shane end up combining and go together to find the cure. As Klaus tells Rebekah that there's only one dose of the cure, she admits the new information to Stefan before snapping his neck so she could find the cure for herself. A day later, Damon tells Rebekah that Katherine stole the cure after indirectly killing Jeremy; they capture and torture Galen Vaughn to get information about Katherine, who was working with him, as well as Hayley, a werewolf friend of Tyler Lockwood. Once they return to Mystic Falls, Rebekah and Damon still try to find Katherine and met a vampire named Will, a former friend of Damon's who was working for Katherine, but Damon kills him before they can learn anything about her whereabouts. He tells Rebekah it's due to his werewolf bite making him unable to be saved, but Rebekah had a vial of Klaus blood that would have cured him. It is eventually revealed that he killed him to avoid sharing the information with Rebekah. When Damon takes Elena to New York City (in part to look for Will's old records of Katherine), Rebekah follows them. Rebekah and Elena team up and steal Damon's car to find Katherine themselves. Rebekah still wants to take the cure herself, and Elena wants to find it and give it to Rebekah before Stefan and Damon find it first and use it on her, ensuring that she stays a vampire. Rebekah and Elena find Katherine in Willoughby, PA. Rebekah takes a vial containing what Katherine says is the cure. After Rebekah drinks it, she loses consciousness. Upon awakening, Rebekah claims that she feels good and alive, but soon learns that it was actually a decoy. Later, she goes to Elijah, who is given the cure by Katherine, and asks him to give it to her so she can be human again. Rebekah and Elijah leave Willoughby together and return to Mystic Falls.
Silas wants the cure to cure himself. He uses the ability to create illusions (the source of this ability is unknown, as he can supposedly no longer perform magic) to take the form of Shane as he left his tomb. He took Bonnie with him, healing her and pretending to be Shane to earn her trust. Bonnie refused at first, but Silas used her grief over Jeremy and her Grams against her, creating a vision of Jeremy asking for help. This gave Silas the power he needed to manipulate and brainwash her into doing his bidding. He sent Bonnie to Damon, so she could be taken back home. Bonnie explained to Damon on the way home what she had learned from "Shane". Bonnie had learned that Qetsiyah had created the Other Side so that if Silas chose to take the cure and die of old age in the tomb, he would be trapped in supernatural purgatory with Qetsiyah for all time, and would be separately from his human lover. He wanted Bonnie to complete the Expression Triangle which would make it so The Other Side no longer existed, and all supernatural beings trapped there would be returned to the realm of the living; completing the triangle would require one more massacre of 12 people (in addition to the two prior massacres that Shane orchestrated, of twelve humans and hybrids, respectively), in this case, witches. Silas later approaches Klaus (still in the form of Shane) in order to strike a bargain; since Klaus is afraid the cure will be used against him, and Silas wanted to take the cure for himself, Klaus should give him the cure and they would both get what they wanted. When Klaus tells him he has no interest in bringing back every dead supernatural creature, many of whom he killed himself, and explains that he isn't afraid of him, Silas retaliates by creating an illusion that Silas had stabbed Klaus in the back with the White Oak Stake and had broken the tip off in his back. This illusion was so strong that it made Klaus believe that he was dying until Caroline made him so angry that he was able to take his mind off of it. That same day, Silas returned to taunt Klaus, this time in the form of Caroline, and hounded him about getting him the cure, threatening to give him nothing but misery until he obtains it. Later, Klaus assisted Silas in acquiring the cure by stalling Rebekah, while Silas assumes her form to trick Elijah into giving the cure, which is now in his possession.
Katerina wanted the cure to exchange it for her freedom from Klaus, after being on the run for 500 years. Katerina found Hayley in New Orleans, and told her that she could help Hayley find information on her biological parents if Hayley gave her information on the cure. Once Hayley had exceeded her usefulness, Katerina sent Will to kill her, as she was now a loose end. Klaus, however, saved Hayley by biting Will. Katerina was in possession of the cure until she gave it to Elijah in American Gothic. Instead in Graduation, Katerina was forced to take the cure by Elena losing her chance to use it as her ticket of freedom.
Stefan and Damon want to find the cure before Rebekah and Elena force Katherine to give it to them and Rebekah uses it. They want it to cure Elena, believing that it will solve the problems caused by Elena turning off her human emotions. Damon now holds the cure in his possession thanks to Alaric.
The TV series
- The TV series is different from the books with this concept. There is only enough of the cure for one person to use.
- Elena force-fed Katherine the cure in Graduation.
- The cure was in Katherine's blood. Then, Silas fed from her and it passed on into him and also turned him into a witch again. Then, Amara fed from Silas in order to become human, so the cure was in her before she died along with the cure in her.
- When Silas drained the cure out of Katherine, Katherine began to rapidly age with her hair turning gray and her teeth falling out. It is later revealed that after having the cure drained from her, that her 500 years is starting to catch up to her, and only had a few months left to live. This wouldn't have happened if the cure wasn't drained from her blood. She would have aged normally had it had not been removed from her blood.
- After the cure was drained from Silas, he did not seem to start rapidly aging immediately as Katherine did. As Silas was not undead, he may not have been affected the same way as Katherine was, or he used witchcraft to halt the effects.
- When vampires go back to being human in the books, they begin aging normally, as if they had never been a vampire.
- In the books, the cure is a rose, while in the TV series, it's a liquid potion in a small vial.
- Damon takes the cure (sniffs the rose meant for Stefan) by accident, but is turned back into a vampire sometime after.
- It is possible if a vampire wanted to be cured a witch can put his or her spirit into a human body like what Esther did with Finn and Kol.
- Amara never drank all of Silas' blood, yet still was cured. (It is possible Silas lied about the need for all of Katherine's blood due to his disdain for the Petrova doppelgängers)
- Had Amara drank the cure off screen, Silas would have been effected by the same aging as Katherine. Though it is possible that since Silas was truly immortal he wasn't effected by time at all or that having never died had some effect on him or it wasn't addressed as Silas died very soon after.
- There now exists a second "cure" for immortality: the blood of the remaining pair of doppelgängers. If a vampire was to drink the doppelgängers blood after the blood has been spelled by the Travelers, the mystical properties of the blood will undo all of the magic that turned the person into a vampire. However, they will be returned to the state they were in when they became a vampire, which is a dead human—a vampire who is "cured" this way will end up dying again in the same way they were killed before they were turned, such as from a snapped neck, tuberculosis, gun shots, drowning, stabbing, etc.
- The cure was not brought up until the now-deceased vampire hunter Connor Jordan returned to Mystic Falls with a hunter's mark. 
- Only Petrova doppelgängers ingested the cure in form of potion (Katherine ingested original cure, and Elena 1994 version of the cure).
- There were three total cure potions, technically one but thanks to the two prison worlds, there are versions of the cure in each other
- Katerina Petrova † (Forced to drinking the cure by Elena)
- Silas † (Cured by drinking Katerina's blood)
- Amara † (Cured by drinking Silas' blood)
- Sloan † (Cured and killed by The Magic Purification Spell)
- Tyler Lockwood † (Cured and killed by The Magic Purification Spell; Resurrected)
- Ivy † (Cured and killed by The Magic Purification Spell)
- Many unnamed vampires † (Cured and killed by The Magic Purification Spell)
- Alaric Saltzman (Cured by The Magic Purification Spell and saved by Josette Parker)
- Tripp Cooke † (Cured and killed by The Magic Purification Spell)
- Elena Gilbert (Cured by drinking the cure - 1994 version)
- Stefan Salvatore † (Cured by injection of the cure - 1994 version)
- Damon Salvatore (Cured by injection of the cure - 1994 version)