It was apparent that the vampires controlled her mind to allow them house-room in her home, let them feed on her without complaint and to do whatever they wanted like a maid. Frederick compelled her to never invite Damon into the house after Fredrick captured Stefan and brought him home to torture him, as a form of retribution against the Salvatores, who the tomb vampires believed to be at fault for their incarceration in the tomb. Alaric was able to trick them into allowing him in, posing as someone having car trouble and asking to borrow their phone. He went into the back room and opened the door for Damon. When Samantha explained that she wasn't allowed to let Damon in, Alaric took Miss Gibbons outside where Damon questioned her on whether any other humans lived in the house; when she confirmed she was the only one, he snapped her neck. Alarmed, Alaric had expected him to just compel her to let him in, but Damon stated it didn't work that way, as she was already compelled against him by Frederick.
It was shown that Pearl, Anna and Harper still lived in the house after Damon and Alaric killed most of the vampires; the others that weren't killed ended up leaving town. Pearl and Harper were later killed by John Gilbert.
Samantha is the English origin and the meaning is "God heard".