Mystic Falls Police Station is the local police force located in Mystic Falls and it was run by the local sheriff, Elizabeth Forbes, who was also part of the Founder's Council. Most of the deputies, if not all, knew about vampires and worked in conjunction with the Council. The station is currently run by Matt Donovan.
Only a small circle of deputies know of the vampires and are usually warned by Sheriff Forbes of their presence, using the term "V5." This term is used by her in The Turning Point and by John Gilbert in Founder's Day.
Damon Salvatore came to the station to deliver vervain to Forbes and promised to help with the vampire issue in order to maintain his cover as a human Founding Family member.
After Vicki Donovan's disappearance, Sheriff Forbes called Matt Donovan, Jeremy and Elena Gilbert, and Stefan Salvatore to the police station for questioning on her whereabouts and how she was acting before she disappeared. None of them had any clue where she had gone except for Elena and Stefan, who knew the truth that Vicki was dead, and who lied about what they knew about it. (162 Candles)
Although they answer to the Sheriff and appear loyal to her, they go behind her with Richard Lockwood and John Gilbert in their plan to kill the vampires in Mystic Falls during Founder's Day although it is unlikely that they knew that John knocked her out and locked her in her office so that she wouldn't stop them.
In the last episode of the season, As I Lay Dying, Sheriff Forbes locked Elena in her office, thinking it was for Elena's own safety. She left two deputies to guard her. Later, Elena escaped by breaking the window with nearby chair and climbing out. in order to rescue Damon.
In Ghost World, Lexi and Elena brought Stefan in the cells to get him back on track.
In 1912, Sheriff locked Alaric in a cell after Meredith told her that he was a number one suspect for the recent murders. Later, after Matt and Elena broke into Meredith's Apartment, the sheriff brought them to her office.
In Requiem for a Dream, Matt was sitting in the sheriff's office looking at the case of Penny Ares. A deputy entered his office asking him about the case. Matt said that it was an accident. It was later revealed that Matt has been promoted to Sheriff.