The Police Station is located in Mystic Falls and it was run by the local sheriff, Elizabeth Forbes, who was also part of the Founder's Council. Most of her deputies, if not all, knew about vampires and worked in conjunction with the Council. The station is currently run by Matt Donovan.
In 2009, there were several attacks on the town's people by vampires who were thought to have left Mystic Falls long ago. To keep the truth hidden, the sheriff, Elizabeth Forbes had Logan Fell, the local news reporter and fellow member of the Council, report the tragedies as animal attacks.
After Vicki Donovan's disappearance, Sheriff Forbes called Matt Donovan, Jeremy and Elena Gilbert, and Stefan Salvatore to the police station for questioning on her whereabouts and how she was acting before she disappeared. None of them had any clue where she had gone except for Elena and Stefan, who knew the truth that Vicki was dead, and who lied about what they knew about it. (162 Candles)
In the last episode of the season, As I Lay Dying, Sheriff Forbes locked Elena in her office, thinking it was for Elena's own safety. Later, Elena escaped by breaking the window with nearby chair and climbing out. in order to rescue Damon.
In 1912, Sheriff locked Alaric in a cell after Meredith told her that he was a number one suspect for the recent murders. Later, after Matt and Elena broke into Meredith's apartment, the sheriff brought them to her office.