Katherine first saw Mikael in 1920's and 90 years later she met with him when trying to awake him up from his long deep sleep. Mikael ends his conversion with Katherine when draining her off her blood. Katherine later plays as Elena to fool both Klaus and Mikael: once Mikael stabbed her, she threw Wolfsbane at the hybrids and Klaus killed him.
In the 1920's after Klaus had fled Chicago, Mikael came up front as a Police officer and asked Stefan Salvatore if he had seen those two persons at the drawings. Katherine was there and watched him ask Stefan of it, after he saw that Stefan had been compelled he left.
Throughout The Vampire Diaries Series
In The Reckoning, Katherine and Jeremy Gilbert find the location of Mikael, in a cemetery where Anna said he'll be. Katherine opens his tomb and Mikael's eyes opens. Katherine tries wake him up for 3 days with no success, once she was able to wake Mikael, he told her to get the dead body away from him and then falls asleep. Mikael then wakes up later and apologizes to Katherine for yelling at her and tells her he has denied himself human blood for as long as he can remember. When Katherine asks him what he eats, Mikael responds by viciously grabbing and feeding on the vampire.
- Mikael: "Get it away from me!"
- Katherine finds out where Mikael is with the help of Jeremy and Anna.
- Mikael drinks Katherine's blood being he only feeds on vampire blood.
- Katherine is one of the few vampires to survive Mikael's wrath.