Enzo's Safe House was a cabin located in some woods outside of Mystic Falls.
Throughout The Vampire Diaries Series
In 2013, Enzo sedated Bonnie Bennett in her dorm room and brought her here when the Armory came for her. He gave her pills, which makes her unlocatable by The Armory through magic, in exchange for research about Alex. In the fall of 2013 Bonnie started falling in love with Enzo. Bonnie decorated the house for the New Year's Eve of 2014. After dinner, the two danced. In 2015 Enzo and Bonnie kissed.
In Somebody That I Used to Know, Enzo, Bonnie and Damon came here to see Rayna, who was located in the storm cellar. Enzo and Damon offered to kill some people on her list in exchange to transfer her link to the Everlastings to Bonnie.
Enzo led Bonnie in to his safe house in Gods and Monsters after she became the Huntress. Bonnie shot him and tried to stake him, but at the same time Damon killed the last member of The Eight Everlastings, which released her from the hunter's curse.
Bonnie spent a lot of time here while Enzo and Damon were missing. Enzo left her clues about the sirens.
In Coming Home Was a Mistake, Bonnie trapped Enzo in the house and told him to turn his humanity back on. When she fainted after she set the cabin on fire, Enzo took her outside. The cabin burned to the ground.
In The Lies Will Catch Up To You, Bonnie met with Enzo in the cabin through a hallucination.
In It's Been a Hell of a Ride, Bonnie spent some time with Enzo in the destroyed cabin