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Elixir

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Silas and I were going to drink the immortality elixir as part of our wedding ceremony, but then everything around me started to die...my wedding flower, the garden trellis, our harvest.
Qetsiyah on her elixir in Original Sin


Immortality TVD 5x03

The Immortality Elixir and Cure

An elixir, also known as a potion, is a liquid concoction with magical or medicinal properties to be taken orally and intended to cure one's ills. They are often made by witches using herbs to imbue them with a variety of supernatural effects similar to those obtained from spells.

A number of potions have appeared in the Vampire Diaries series that can be used to damage, such as poisons, as well as to cure, such as elixirs and tonics with the most notable being the Elixir for Immortality.

Throughout The Vampire Diaries Series

Season One

Vervain

Katherine is burned by vervain

In Children of the Damned, it was revealed that in 1864, Pearl was providing vervain given by Honoria Fell in the form of an elixir to the townspeople in order to combat the vampires in town. She sold it at her apothecary order to be inconspicuous even though she was a vampire herself. Showing the elixir to Katherine which burnt her, she warned her of the council's growing threat.

Season Two

Elixir

Resuscitation Elixir

In The Last Day, it was revealed that in 1492, Elijah had requested a potion that would resurrect Katerina after the sacrifice ritual. However, Katerina escaped before knowing of the elixir, and became a vampire instead. 518 years later, Elijah planned to giving the elixir to Elena, however after being forced to drink vampire blood, the potion’s effect became useless. The life-restoring elixir is likely still in Elijah's possession. It's unknown if this would still work or not, considering it's unknown if it only works in doppelgängers or any supernatural being.

Season Three

ImmortalitySpell3

In Ordinary People, it was revealed that the Originals were created by Esther with a modified Immortality Spell based on Qetsiyah's elixir. Making an Immortality potion using blood from Amara's doppelgänger line. Esther performed the spell that enhanced the doppelganger blood. She called upon the sun for life and the white oak tree for immortality. That night, Esther mixed the blood of Tatia, the first Petrova doppelganger, into the wine her children were to drink at supper. After drinking the wine, he drove his sword through each of his children's hearts. After, he made them drink the blood of a nearby villager, completing the ritual and thus, creating the first vampires.

In Do Not Go Gentle, she recreates the potion, but with Alaric. Esther channels the magical hotspot where Klaus killed her a thousand years ago. Esther uses the same spell she used a thousand years ago but instead of using the blood of Tatia, the spell is bound to the blood of Elena, another Petrova doppelganger. Binding to the blood of Elena gives Esther the ability to bind Alaric's life to Elena's not that of the white oak. Esther also binds the last remaining white oak stake to the Gilbert Ring, meaning that the stake will not burn up in its victim.

Season Five

Elixir2

Immortality Elixir stolen

In Original Sin, it is revealed that the Immortality spell that was used to turn Silas and Amara into Immortals was created in the form of an elixir created by the powerful witch, Qetsiyah. Qetsiyah was under the impression that Silas and her would drink the elixir at their wedding. However, Qetsiyah was left standing at the altar, only to learn that Silas had stolen the Immortality elixir, which he had shared with his true love, Amara. Qetsiyah was so furious at this betrayal that she created the Other Side and the cure for immortality, in an effort to punish him by forcing him to be stuck with her on the Other Side for eternity. It was also revealed that the cure was in the form of a potion.

Season Seven

Shamani1

Shamanic tea of protection

In This Woman's Work, the tea of protection was introduced in a flashback. The tea itself was part of a ritual casted by The Eight Everlastings. The Shaman mentioned that the tea would make Rayna Cruz strong, and immune to magic. In Kill 'Em All, Rayna forfeits her remaining life, giving it up to Bonnie, however, moments before she plunges the dagger through her heart, her and the Shamon betray Damon, passing all the traits and qualities of Huntress to Bonnie. In Requiem for a Dream, Bonnie awakes from her mystical slumber, imbued with the abilities of the Huntress, of which nullifies, or blocks her magic, possibly due to the tea of protection that gives immunity to magic, drank by the previous hunter. Following the destruction of the last Everlasting, it was revealed that Bonnie's magic did not return, possibly due to a side affect from the shamanistic transfer spell.

Throughout The Originals Series

Season One

In Long Way Back From Hell, Genevieve was seen creating a potion in a mortar. She mixed unknown herbs along with her blood and Rebekah's blood. She gave this potion to Klaus in order to show him Genevieve's past memories; and show him the truth about Marcel and Rebekah. In that same episode in a flashback, Genevieve was shown giving sick people a "simple herbal remedy" as stated by her in order to ease the sicks pain.

Elixir4

In Le Grand Guignol, Céleste creates a cure to reverse the Crescent Curse at Hayley's request using herbs to make a potion. Céleste told Hayley that the elixir needed to be boiled under the full moon, after that the curse would be broken.

Season Two

In The Brothers That Care Forgot, Davina used a spell from Esther's Grimoires. The elixir required using milk, herbs, and channeling dark objects. She managed to turn her blood into poison; strong enough to subdue Klaus.

In Save My Soul, After Dahlia killed Mathias; to save herself and her baby; Freya took a bottle of Dahlia's strongest poison In attempt to kill both herself and her child.
Tonic

In Night Has A Thousand Eyes, Freya creates a tonic for her family to combat Dahlia's Kenning. As explained by Freya, this elixir would protect the one who drank from Dahlia's kenning spells.

Season Three

ImmortalitySpell2

In Behind the Black Horizon, with the help of Vincent Griffith, Lucien Castle remakes the immortality elixir used by Esther Mikaelson to turn her children into vampires. Lucien uses Freya Mikaelson's blood to bind the spell, infuses the blood with werewolf venom and the last remaining white oak bullet. Together, this made a serum that enhanced Lucien to a far superior species than the Mikaelson family.

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