|“||You know you are not going anywhere, Damon. And I`m not your new partner in vampire crime. Fix things with Stefan and Elena. Don't let your pride leave you all alone.||”|
After Brian Walters was murdered, Damon suspects Meredith killing her ex-boyfriend. He confronts her at the hospital, discovering she signed her ex-boyfriend's death certificate. She suggests its a bigger mystery on how Alaric was on his death bed when he arrived at the hospital, and later walking away without a scratch. Damon attempted to leave, but Meredith injected him with vervain, stealing his blood while he was knocked out. She later revealed that she used his blood to cure her patients, as she hates losing patients.
Two days later, Elena died during a car accident caused by Rebekah. As Alaric died, Damon immediately knew Elena was dead too, because Esther bound Ric's life to Elena's. Enraged, he showed up at the hospital, demanding Meredith to tell him where Elena was. Meredith explained that she had no choice to save her, since her injuries were way worse than she had let on, and gave her vampire blood. Meanwhile, Elena had woken up, now as a vampire in transition.
In The Rager, Damon calls Meredith for help after he gets trapped with a bomb at Connor's trailer. While cutting the arrows out of Damon, she see's him rejecting a call from Elena. Meredith tells him he's a good brother, the fact that he is trapped to a bomb while Stefan is playing vampire with Elena, who broke his heart. Meredith tells him he does a really good job acting like it doesn't suck. She then successfully frees Damon from the bomb by cutting the arrows out of his chest. Damon, Klaus, Jeremy, and Meredith plan to trap Connor to question him.
Jeremy and Connor secretly follow Meredith, whose wearing a bandage on her neck making it look like she's been fed off of into the storage room. Connor goes into the room but finds his bombs, along with Damon and Klaus. After Connor activates the bomb blowing up the storage room, Meredith is very unhappy by what happened, stating that there are sick patients who don't need a bomb so close to their rooms. Damon assures her no one got hurt, and offers her to drink with him. She says no and that she's not his new partner in crime, and to fix things with Elena and Stefan and not to let his pride leave him all alone.
- In the novels, Meredith, and Damon do not usually interact unless other characters are present, while in the series, Meredith has greater interaction with Damon.